Here, we report the novel use of Laser Speckle Rheology (LSR) for measuring anticoagulation and haemodilution status in whole blood allmän - core.ac.uk

Optotune laser speckle reducers remove local interferences and significantly reduce speckle noise in laser systems by dynamically diffusing the laser beam. Offering a compact size, integrated drive electronics, and vibration-less speckle reduction, Optotune laser speckle reducers are ideal for beam homogenization, 3D scanning, metrology, microscopy, and interferometry.

Approach: In LSR, the shear viscoelastic modulus is measured from the time-variant speckle intensity fluctuations reflected off the tissue. Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the frequency-dependent viscoelastic properties of hydrogels. In LSR, a coherent laser beam illuminates the specimen and a high-speed camera acquires the time-varying speckle images. We introduce a novel technology, termed laser speckle micro-rheology (LSM) that offers the unique capability to map the viscoelastic properties of the tissue microenvironment.

Laser speckle rheology

Combined neutron reflectometry and rheology. G. C. Ciftci et al., "Tailoring of rheological properties and structural "Complete spatial coherence characterization of quasi-random laser emission in European oak : A digital speckle photography study," Holzforschung, vol. Laser physics (7.5) Supervised PhD thesis: Anders Ericsson, "Rheology of fibre filled polypropylene", graduated EPFL composites by speckle pattern interferometry” Proceedings of the ICCM-9, Madrid, July 12-16, have shown large temporal variations in the detected perfusion estimate, due to speckle. The consistency and viscosity can be described by fluid rheology and are measures the pressure field in an ultrasound beam with laser light.

Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the frequency-dependent viscoelastic properties of hydrogels. In LSR, a coherent laser beam illuminates the specimen and a high-speed camera acquires the time-varying speckle images.

Speckle can often be avoided, e.g. by using a light source with sufficiently large optical bandwidth (short coherence length ) such as a superluminescent source . Laser speckle flowmetry The technique for LSF has been described in detail else-where (Dunn et al., 2001).

We have developed and investigated a novel optical approach, Laser Speckle Rheology (LSR), to evaluate a patient’s coagulation status by measuring the viscoelastic properties of blood during coagulation. In LSR, a blood sample is illuminated with laser light and temporal speckle intensity fluctuations are measured using a high-speed CMOS camera.

MM Tripathi, Z Hajjarian, EM Van Cott, SK Nadkarni. Biomedical optics express 5 (3), 817-831, 14 May 2019 temporal resolution for images of blood flow was achieved with laser speckle contrast imaging (LSCI)9–12 by measuring the spatial speckle 7 Sep 2018 Although rheology provides a method to access the product viscosity, it lacks non -contact full-field monitoring. We apply a simple correlation. Keywords: Speckle, Correlation spectroscopy, Dynamical properties, Optical properties. 1. measurement and illumination with a femtosecond laser of variable spectral speckle rheology measurements, Opt. Exp. 22 (2014) 6349- 6361.

Laser Speckle Rheology (LSR) is an optical technique to evaluate the viscoelastic properties by analyzing the temporal fluctuations of backscattered speckle patterns. Variations of optical absorption and reduced scattering coefficients further modulate speckle fluctuations, posing a critical challenge for quantitative evaluation of viscoelasticity. We introduce a novel technology, termed laser speckle micro-rheology (LSM) that offers the unique capability to map the viscoelastic properties of the tissue microenvironment.
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The LSR instrument is unique in that it probes larger depths (up to 2mm), over a large field of view (several cm), within minutes and can be operated with the push of a button at a fraction of the cost (~$5,000-10,000). Imaging modalities such as ultrasound, MRI and OCT can also effectively measure tissue stiffness. Laser speckle rheology (LSR) offers a new, noncontact optical approach. Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the frequency-dependent viscoelastic properties of hydrogels. In LSR, a coherent laser beam illuminates the Laser Speckle Rheology (LSR) offers a novel, non-contact optical approach for evaluating the frequency-dependent viscoelastic properties of hydrogels.

400µm travel at 300Hz). Assessing blood coagulation status with laser speckle rheology. MM Tripathi, Z Hajjarian, EM Van Cott, SK Nadkarni.
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Optotune laser speckle reducers remove local interferences and significantly reduce speckle noise in laser systems by dynamically diffusing the laser beam. Offering a compact size, integrated drive electronics, and vibration-less speckle reduction, Optotune laser speckle reducers are ideal for beam homogenization, 3D scanning, metrology, microscopy, and interferometry.

Biomedical Optics Laser speckle rheology (LSR) offers a new noncontact optical approach. LSR uses an inexpensive laser—similar to a common laser pointer to shine laser light on tissue—plus a camera to image speckle patterns reflected from light-scattering particles in the sample. When laser light which has been scattered off a rough surface falls on another surface, it forms an "objective speckle pattern". If a photographic plate or another 2-D optical sensor is located within the scattered light field without a lens, a speckle pattern is obtained whose characteristics depend on the geometry of the system and the wavelength of the laser. 2017-08-23 · Laser speckle, a random intensity pattern that occurs by the interference of coherent light scattered from tissue, is exquisitely sensitive to the passive Brownian motion of intrinsic light Laser Speckle Rheology (LSR) is an optical technique to evaluate the viscoelastic properties by analyzing the temporal fluctuations of backscattered speckle patterns. Variations of optical absorption and reduced scattering coefficients further modulate speckle fluctuations, posing a critical challen ….

Wikimedia Commons · A typical laser speckle pattern. · Laser Speckle Rheology Nadkarni Laboratory for Optical · How Cold Atoms Might Help Physicists

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Speckle patterns can severely degrade the image quality of laser projection displays, or disturb position measurements with laser pointers.